Vrije Universiteit Brussel


Research Page of Goedele Alaerts

Last update: 18 May 2012

General Information

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CIVIL STATUS :

  • Born on the 23th of July 1980 in Brussel
  • Married
  • Belgian Nationality

EDUCATION :

  • Ph.D. student in Pharmaceutical Sciences (2004 - 2012)
    Title: Chromatographic fingerprints of herbal extracts as tools for identification or quality control. In preparation.
    Promotors: Prof. Dr. Y. Vander Heyden and Prof. Dr. J. Smeyers-Verbeke
    Department of Analytical Chemistry and Pharmaceutical Technology (FABI)
    Vrije Universiteit Brussel (VUB) - Belgium

  • Master degree in Pharmaceutical Sciences (July 2004)
    Faculteit Geneeskunde en Farmacie (GF)
    Vrije Universiteit Brussel (VUB) - Belgium

ACADEMIC CAREER :

  • Assistent for Master in Pharmaceutical Sciences (2005 - 2010)
    Department of Analytical Chemistry and Pharmaceutical Technology (FABI)
    Vrije Universiteit Brussel (VUB) - Belgium

  • Guest professor and lector for Bachelor in Medical laboratoriumtechnology (MLT) and Bachelor in Farmaceutical & biological laboratoriumtechnology (FBT) (2010-2011)
    Biomedical laboratoriumtechnology (BLT)
    Hogeschool West-Vlaanderen (Howest) - Belgium

RESEARCH TOPICS :

  • Chromatographic fingerprints of herbal extracts as tools for identification or quality control: experimental set-up and data analysis (2005-2012)
    • Sample treatment: sample collection, lyophilisation, extraction (Ultrasonic, Liebig, Soxhlet)
    • Method development: HPLC/UV/ELS and HPLC/DAD/ELS, experimental designs, assays
    • Validation and quality control: methodvalidation set-ups, linearity
    • Data analysis: Similarity Analysis (correlation and distance measurements), Exploratory Data Analysis (Principal Component Analysis, Projection Pursuit, Hiërarchical Clustering Analysis)

  • Capillary Electrochromatography (CEC): column packing, method development (2004-2005)

Publications

  • The use of entire chromatographic fingerprints as identification tool to distinguish Artemisia vulgaris, A. absinthium, A. annua and A. capillaris simultaneously.
    G. Alaerts, M. Merino-Arévalo, H. Logie, J. Van Erps, B. Dejaegher, S. Pieters, L. Schockaert, J. Smeyers-Verbeke, Y. Vander Heyden.
    In preparation.

  • Similarity analyses of chromatographic fingerprints as tools for identification and quality control of green tea.
    G. Alaerts, J. Van Erps, S. Pieters, M. Dumarey, A.M. van Nederkassel, M. Goodarzi, J. Smeyers-Verbeke, Y. Vander Heyden.
    Journal of Chromatography B, Special Issue ‘Chemometrics in chromatography’, In press, accepted manuscript.
    doi: 10.1016/j.jchromb.2012.04.031

  • Evaluation of pressurized capillary electrochromatography in a screening for possible antioxidant molecules in Mallotus fingerprints: challenges, potentials and prospects.
    S. Pieters, C. Tistaert, G. Alaerts, K. Bodzioch, D. Mangelings, B. Dejaegher, C. Riviere, M. Chau Van, J. Quetin-Leclerq, Y. Vander Heyden.
    Talanta, 83 (2011) 1188-1197
    doi:10.1016/j.talanta.2010.08.006

  • Exploratory analysis of chromatographic fingerprints to distinguish Rhizoma Chuanxiong and Rhizoma Ligustici.
    G. Alaerts, M. Merino-Arévalo, M. Dumarey, B. Dejaegher, N. Noppe, N. Matthijs, J. Smeyers-Verbeke, Y. Vander Heyden.
    Journal of chromatography A, 1217 (2010) 7706-7716.
    doi: 10.1016/j.chroma.2010.10.010

  • Recent developments in chromatographic fingerprints for herbal medicines: set-up and data analysis. Invited review.
    G. Alaerts, B. Dejaegher, J. Smeyers-Verbeke, Y. Vander Heyden.
    Combinatorial Chemistry & High Throughput Screening, 13 (2010) 900-922
    doi:10.2174/138620710793360284

  • Methodology to develop liquid chromatographic fingerprints for the quality control of herbal medicines.
    B. Dejaegher, G. Alaerts, N. Matthijs.
    Acta Chromatographica 22, (2010) 237–258
    doi: 10.1556/AChrom.22.2010.2.7

  • Chromatographic fingerprint development for herbal extracts: a screening and optimization methodology on monolithic columns.
    G. Alaerts, N. Matthijs, J. Smeyers-Verbeke, Y. Vander Heyden.
    Journal of Chromatography A, 1172 (2007) 1-8
    doi: 10.1016/j.chroma.2007.07.080

  • Broad-spectrum separations in metabolomics using enhanced polar LC stationary phases: a dedicated evaluation using plant metabolites.
    R. t’Kindt, G. Alaerts, Y. Vander Heyden, D. Deforce, J. Van Bocxlaer.
    Journal of Separation Science 30 (2007) 2002–2011
    doi: 10.1002/jssc.200700077

  • Sequential uniform designs for fingerprints development of Ginkgo biloba extracts by capillary electrophoresis.
    Y.-B. Ji, G. Alaerts, C.-J. Xu, Y.-Z. Hu and Y. Vander Heyden.
    Journal of Chromatography A 1128 (2006) 273-281
    doi: 10.1016/j.chroma.2006.06.053

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Oral Presentations

  • Data handling of chromatographic herbal fingerprints.
    B. Dejaegher, M. Goodarzi, G. Alaerts, C. Tistaert, M. Dumarey, Y. Vander Heyden.
    CAC-2012, 13th conference on Chemometrics in Analytical Chemistry, 25-29 June 2012, Budapest, Hungary.

  • Basic unsupervised and supervised multivariate data analysis.
    B. Dejaegher, C. Tistaert, M. Goodarzi, M. Dumarey, G. Alaerts, Y. Vander Heyden.
    WWorkshop Metabolomics, Basics and Applications to Plant Sciences, 23-27 April 2012, Leiden, The Netherlands.

  • Herbal Fingerprints: Extraction of Information.
    Y. Vander Heyden, C. Tistaert, G. Alaerts, B. Dejaegher.
    HTC12, 12th International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analysers, 1-3 February 2012, Bruges, Belgium.

    Herbal fingerprints: development and extraction of information.
    Y. Vander Heyden, G. Alaerts, M. Dumarey, C. Tistaert, B. Dejaegher.
    RDPA2011, 14th International Meeting on Recent Developments in Pharmaceutical Analysis, 21-24 September 2011, Pavia, Italy.

    Chromatographic herbal fingerprints: development, validation and data handling.
    B. Dejaegher, C. Tistaert, M. Goodarzi, G. Alaerts, Y. Vander Heyden.
    Kwaliteitsaspecten van Geneeskrachtige Planten, Nederlandse Vereniging voor GeneeskruidenOnderzoek (NVGO), 27 May 2011, Strombeek-Bever, Belgium.

  • Basic unsupervised and supervised multivariate data analysis.
    B. Dejaegher, C. Tistaert, M. Goodarzi, M. Dumarey, G. Alaerts, Y. Vander Heyden.
    Workshop Metabolomics: Basics and Applications to Plant Sciences, 11-15 April 2011, Leiden, The Netherlands.

  • Chromatographic herbal fingerprints: Development, Validation and Data Handling.
    B. Dejaegher, C. Tistaert, M. Dumarey, G. Alaerts, Y. Vander Heyden.
    Meeting Research on fingerprints of Chinese Materia Medica to develop standard and research protocols evaluating their identity, safety and reproducibility, 17 December 2010, Vrije Universiteit Brussel, Jette.

  • Data handling of chromatographic herbal fingerprints.
    B. Dejaegher, C. Tistaert, M. Dumarey, G. Alaerts, Y. Vander Heyden.
    12th International Conference on Chemometrics in Analytical Chemistry (CAC-2010), 18-21 October 2010, Antwerpen.

  • Chromatographic fingerprints for herbal extracts: set-up and data analysis.
    G. Alaerts, M. Dumarey, J. van Erps, S. Pieters, M. Merino-Arévalo, N. Matthijs, B. Dejaegher, J. Smeyers-Verbeke, Y. Vander Heyden.
    ISCNP-ISDNP 2010, 7th International Symposium on Chromatography of Natural Products, combined with the 6th International Symposium of the International Society for the Development of Natural Products: The application of analytical methods for the development of natural products, 14-17 June 2010, Lublin, Poland.

  • Chromatographic fingerprint development for herbal extracts.
    G. Alaerts, M. Merino-Arévalo, N. Matthijs, J. Smeyers-Verbeke, Y. Vander Heyden.
    14th Forum of Pharmaceutical Sciences, Belgian Society of Pharmaceutical Sciences, 14-15 May 2009, Floreal, Blankenberge.

  • Pressurized Capillary Electrochromatography as an alternative technique to High-Performance Liquid Chromatography for the indication of active compounds in Mallotus species.
    S. Pieters, K. Bodzioch, C. Tistaert, G. Alaerts, B. Dejaegher, D. Mangelings, Y. Vander Heyden.
    14th Forum of Pharmaceutical Sciences, Belgian Society of Pharmaceutical Sciences, 14-15 May 2009, Floreal, Blankenberge.

  • Chromatographic fingerprint development for herbal extracts.
    G. Alaerts, M. Merino-Arévalo, N. Matthijs, J. Smeyers-Verbeke, Y. Vander Heyden.
    FABI meetings, 8 May 2009, Vrije Universiteit Brussel, Jette.

  • Pressurized Capillary Electrochromatography as an alternative technique to High-Performance Liquid Chromatography for the indication of active compounds in Mallotus species.
    S. Pieters, K. Bodzioch, C. Tistaert, G. Alaerts, B. Dejaegher, D. Mangelings, Y. Vander Heyden.
    FABI meetings, 8 May 2009, Vrije Universiteit Brussel, Jette.

  • Herbal fingerprints: development and extraction of information.
    Y. Vander Heyden, G. Alaerts, M. Dumarey.
    ISCNP-ISDNP 2008, 6th International symposium on chromatography of natural products, The application of chromatographic methods in phytochemical & biomedical analysis (ISCNP 2008), 15-18 June 2008, Lublin, Poland.

  • Chromatographic fingerprint development for herbal extracts: a screening and optimization methodology on monolithic columns.
    G. Alaerts, N. Matthijs, J. Smeyers-Verbeke, Y. Vander Heyden.
    13th Forum of Pharmaceutical Sciences, Belgian Society of Pharmaceutical Sciences, 11-12 October 2007, Sol Cress, Spa.

  • Chromatographic fingerprint development for herbal extracts: a screening and optimization methodology on monolithic columns.
    G. Alaerts, N. Matthijs, J. Smeyers-Verbeke, Y. Vander Heyden.
    FABI meetings, 8 October 2007, Vrije Universiteit Brussel, Jette.

  • The separation of neuromediators by means of Capillary Electrochromatography.
    G. Alaerts, D. Mangelings, Y. Vander Heyden.
    Meeting with Sanofi Synthelabo, 25 March 2005, Vrije Universiteit Brussel, Jette.

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Poster Presentations

  • Data handling of chromatographic herbal fingerprints.
    B. Dejaegher, C. Tistaert, M. Dumarey, G. Alaerts, Y. Vander Heyden.
    SSC12, 12th Scandinavian Symposium on Chemometrics, 7-10 June 2011, Billund, Denmark.

  • Pressurized capillary electrochromatography, a useful technique to screen for antioxidant compounds in Mallotus fingerprints?
    S. Pieters, K. Bodzioch, C. Tistaert, G. Alaerts, B. Dejaegher, D. Mangelings, Y. Vander Heyden.
    Recent Developments in Pharmaceutical Analysis 2009, 9-12 September 2009, University of Milan, Italy.

  • Distinguishing Artemisia vulgaris from related Artemisa species using chromatographic fingerprints.
    G. Alaerts, L. Schockaert, J. Smeyers-Verbeke, Y. Vander Heyden.
    HPLC 2009, International Symposium on High-Performance Liquid Phase Separations and Related Techniques, 28 June - 2 July 2009, Dresden, Germany.

  • Chromatographic fingerprint development strategy for herbal extracts.
    G. Alaerts, M. Merino-Arévalo, N. Matthijs, J. Smeyers-Verbeke, Y. Vander Heyden.
    HPLC 2009, International Symposium on High-Performance Liquid Phase Separations and Related Techniques, 28 June - 2 July 2009, Dresden, Germany.

  • Screening for antioxidant compounds in Mallotus species using partial least squares regression models built on pressurized capillary electrochromatography fingerprints.
    S. Pieters, K. Bodzioch, C. Tistaert, G. Alaerts, B. Dejaegher, D. Mangelings, Y. Vander Heyden.
    PhD course on Process Analytical Technology (PAT), 21-26 June 2009, Technical University of Denmark, Denmark.

  • Screening for antioxidant compounds in pressurized capillary electrochromatography fingerprints from Mallotus species using partial least squares algorithms.
    S. Pieters, K. Bodzioch, C. Tistaert, G. Alaerts, B. Dejaegher, D. Mangelings, Y. Vander Heyden.
    25th Annual Symposium on Chemometrics: Dynamic Chemometrics, 28 May 2009, Delft, Nederland.

  • Chromatographic fingerprint development for herbal extracts: parameters to evaluate the global separation quality.
    G. Alaerts, J. Van Erps, N. Matthijs, Y. Vander Heyden
    PBA 2008, 19th International Symposium on Pharmaceutical and Biomedical Analysis, 8 -12 June 2008, Gdansk, Poland.

  • Chromatographic fingerprint development for Rhizoma Chuanxiong and Rhizoma Ligustici.
    G. Alaerts, M. Van Der Stock, N. Matthijs, J. Smeyers-Verbeke, Y. Vander Heyden.
    RDPA 2007, 12th International Meeting on Recent Developments in Pharmaceutical Analysis, 23-26 September 2007, Island of Elba, Italy.

  • Chromatographic fingerprint development for Rhizoma Chuanxiong and Rhizoma Ligustici.
    G. Alaerts, M. Van Der Stock, N. Matthijs, J. Smeyers-Verbeke, Yvan Vander Heyden.
    The XXXIth symposium Chromatographic methods of investigating the organic compounds, Institute of Chemistry, Silesian University, 4-6 June 2007, Katowice - Szczyrk, Poland.

  • Chromatographic fingerprint development for Rhizoma Chuanxiong and Rhizoma Ligustici.
    G. Alaerts, M. Van Der Stock, N. Matthijs, J. Smeyers-Verbeke, Y. Vander Heyden.
    HPLC 2007 Symposium, 17-21 June 2007, Gent, Belgium.

  • Fingerprint development for herbs: a screening and optimization HPLC/UV methodology on monolithic columns.
    G. Alaerts, N. Matthijs, J. Smeyers-Verbeke, Y. Vander Heyden.
    The jubilee XXXth symposium Chromatographic methods of investigating the organic compounds, Institute of Chemistry, Silesian University, 12-14 June 2006, Katowice - Szczyrk, Poland.

  • Fingerprint development for herbs: a screening and optimization HPLC/UV methodology on monolithic columns.
    G. Alaerts, N. Matthijs, J. Smeyers-Verbeke, Y. Vander Heyden.
    DA 2006, Drug Analysis Symposium, 16-19 May 2006, Namur, Belgium.

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Memberships


  • Belgische genootschap voor Farmaceutische Wetenschappen (BGFW) (Belgian Society of Pharmaceutical Sciences)

  • Koninklijke Vlaamse Chemische Vereniging (KVCV)

  • Jeugd, Cultuur en Wetenschap vzw (JCW)

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Coordinates

Goedele Alaerts
Vrije Universiteit Brussel (VUB) - Belgium
Faculteit Geneeskunde en Farmacie (GF)
Center for Pharmaceutical Research (CePhaR)
Department of Analytical Chemistry and Pharmaceutical Technology (FABI)
Email: Goedele.Alaerts@gmail.com

©1997-2005 • FABI • Vrije Universiteit Brussel • Faculteit Geneeskunde & Farmacie
Laarbeeklaan 103 • 1090 Jette • Tel.: 02/477.47.37 • Fax.: 02/477.47.35 • fabi@vub.ac.be