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Research Page of
Debby Mangelings
Last update: 30/03/2012
General Information
 CIVIL STATUS :
- Born on the 25th of November 1978
- Belgian
- Partner of Kristof, mother of Senne
EDUCATION :
- 29 June 2001: Degree in Pharmacy obtained at the Vrije Universiteit Brussel (VUB) - Belgium
- 20th of March 2006: Degree of Ph.D. in Pharmaceutical Sciences.
Title of the thesis: "Evaluation of Capillary
Electrochromatography as Chiral Separation Technique - Definition of a Generic Separation Strategy"
ACADEMIC CAREER :
- October 2001: Ph.D. student in Pharmaceutical Sciences
Department of Analytical Chemistry and Pharmaceutical Technology (FABI)
Vrije Universiteit Brussel (VUB) - Belgium
- October 2006: Postdoctoral Fellow of the Research Foundation - Flanders (FWO)
- October 2009: Part time staff member "docent"
- October 2010: Full time staff member "docent"
RESEARCH TOPICS :
- Analytical Chemistry:
Chiral Separations
Monolithic stationary phases
Miniaturized separation techniques
Capillary Electrochromatography
High Performance Liquid Chromatography
Capillary Electrophoresis
Supercritical Fluid Chromatography
- Chemometrics:
Experimental design
Publications
In books
- 1. "Chiral separations"
Y. Vander Heyden, D. Mangelings, N. Matthijs and C. Perrin
Chapter in the "Handbook of Pharmaceutical Analysis by HPLC",
S. Ahuja and M. Dong (Eds.), Elsevier, Amsterdam, 2005, pp. 447-498.
- 2. "Screening approaches for chiral separations"
D. Mangelings and Y. Vander Heyden
Chapter in “Advances in Chromatography, volume 46”,
E. Grushka, N. Grinberg (Eds.), Taylor and Francis, Florida, 2008, pp.175-211
- 3. "Recent applications in Capillary Electrochromatography"
D. Mangelings and Y. Vander Heyden
Chapter in “Chiral Separations By Capillary Electrophoresis”, A. Van Eeckhaut, Y. Michotte (Eds.),
Taylor and Francis, Florida, 2010, pp. 459-500
- 4. "Application of monolithic chromatography in pharmaceutical analysis"
D. Mangelings and Y. Vander Heyden
Chapter in “Monolithic Chromatography and its modern applications”, P. Wang (Ed.),
ILM Publications, UK, 2010, pp. 177-213.
- 5. "Chiral Separations by Capillary Electrophoresis"
D. Mangelings and Y. Vander Heyden
Chapter in “Chiral Separation Methods for Pharmaceutical and Biotechnology Products”, S. Ahuja (Ed.),
John Wiley and Sons, New Jersey, 2010, pp. 331 - 382.
- 6. "High-Throughput Screening and Method-Development Strategies to
Separate Chiral Drug Compounds in HPLC, SFC and CE"
H. Ates, D. Mangelings and Y. Vander Heyden
Chapter in “Chiral Separation Methods for Pharmaceutical and Biotechnology Products”, S. Ahuja (Ed.),
John Wiley and Sons, New Jersey, 2010, pp. 383 – 416.
In journals
- 1. "Screening approach for chiral separation of pharmaceuticals Part II. Reversed-phase liquid chromatography"
C. Perrin, N. Matthijs, D. Mangelings, C. Granier-Loyaux, M. Maftouh, D.L. Massart and Y. Vander Heyden
Journal of Chromatography A 966 (2002) 119-134.
- 2. "Enantioseparations of basic and bifunctional pharmaceuticals in capillary electrochromatography
using polysaccharide stationary phases"
D. Mangelings, N. Hardies, M. Maftouh, C. Suteu, D.L. Massart and Y. Vander Heyden
Electrophoresis 24 (2003) 2567-2576.
- 3. "Optimisation of the chlorthalidone chiral separation by capillary electrochromatography using an
achiral stationary phase and cyclodextrin in the mobile phase"
D. Mangelings, C. Perrin, D.L. Massart, M. Maftouh,
S. Eeltink, W.Th. Kok, P.J. Schoenmakers and Y. Vander Heyden
Analytica Chimica Acta 509 (2004) 11-19.
- 4. "Comparison of the miniaturized techniques capillary electrochromatography and
capillary liquid chromatography for the chiral separation of chlorthalidone"
D. Mangelings, M. Maftouh, D.L. Massart and Y. Vander Heyden
Journal of Pharmaceutical and Biomedical Analysis 35 (2004) 789-799.
- 5. "Compaction of enteric-coated pellets: influence of formulation and process
parameters on tablet properties and in vivo evaluation"
A. Debunne, C. Vervaet, D. Mangelings and J.P. Remon
European Journal of Pharmaceutical Sciences 22 (2004) 305-314.
- 6. "Enantioseparations by capillary electrochromatography: differences exhibited by
normal- and reversed-phase versions of polysaccharide stationary phases "
D. Mangelings, M. Maftouh, D.L. Massart and Y. Vander Heyden
Electrophoresis 25 (2004) 2808-2816.
- 7. "Chemometric modelling of the catalytic hydrogenation of bicarbonate to formate in aqueous
media"
J. Elek, D. Mangelings, F. Joó and Y. Vander Heyden
Reaction Kinetics and Catalysis Letters 83 (2004) 321-328.
- 8. "Development and validation of an HPLC method with post-column derivatisation to assay
N-acetylcysteďne in plasma"
Y. Vander Heyden, D. Mangelings, J. Van Brempt and H. Spapen
Acta Chromatographica 14 (2004) 149-164.
- 9. "Separation strategy for acidic chiral pharmaceuticals
with capillary electrochromatography on polysaccharide stationary phases"
D. Mangelings, I. Tanret, N. Matthijs, M. Maftouh, D.L. Massart and Y. Vander Heyden
Electrophoresis 26 (2005) 818-832.
- 10. "Enantioselective capillary electrophoretic separation of tryptophane- and tyrosine-methylesters
in a dual system with a tetra-oxadiaza-crown ether derivative and a cyclodextrin"
J. Elek, D. Mangelings, T. Iványi, I. Lázár and Y. Vander Heyden
Journal of Pharmaceutical and Biomedical Analysis 38 (2005) 601-608.
- 11. "Strategy for the chiral separation of non-acidic pharmaceuticals using capillary electrochromatography"
D. Mangelings, J. Discry, M. Maftouh, D.L. Massart and Y. Vander Heyden
Electrophoresis 26 (2005) 3930-3941.
- 12. "Capillary electrochromatographic chiral separations with
potential for pharmaceutical analysis" (review article)
D. Mangelings, M. Maftouh and Y. Vander Heyden
Journal of Separation Science 28 (2005) 691-709.
- 13. "Generic capillary electrochromatographic screening and optimization strategies for
chiral method development"
D. Mangelings, M. Maftouh, D.L. Massart and Y. Vander Heyden
LC-GC Europe 19 (2006) 40-47.
- 14. "Newly synthetized tetra-oxadiaza-crown ether derivatives versus commercialized crown-ethers in the
separation of positional isomers with capillary electrophoresis"
P. Forlay-Frick, D. Mangelings, T. Iványi, I. Lázár, K. Héberger and Y. Vander Heyden
Journal of Pharmaceutical and Biomedical Analysis 41 (2006) 1164-1170.
- 15. "Interlaboratory study of a NACE method for the determination of R-timolol content in S-timolol maleate:
Assessment of uncertainty"
R.D. Marini, C. Groom, F.R. Doucet, J. Hawari, Y. Bitar, U. Holzgrabe, R. Gotti, J. Schappler, S. Rudaz,
R. Mol, G.W. Somsen, G.J. De Jong, P.T.T. Ha, J. Zhang, A. Van Schepdael, J. Hoogmartens, W. Briône, A. Ceccato,
B. Boulanger, D. Mangelings, Y. Vander Heyden, W. Van Ael, I. Jimidar, M. Pedrini, A.-C. Servais, M. Fillet,
J. Crommen, E. Rozet, Ph. Hubert
Electrophoresis 27 (2006) 2386-2399.
- 16. "The future of high pressure liquid chromatography: Do we need porosity or do we need pressure?"
G. Desmet, D. Cabooter, P. Gzil, H. Verelst, D. Mangelings, Y. Vander Heyden, D. Clicq
Journal of Chromatography A 1130 (2006) 158-166.
- 17. "Enantiomeric impurity determination of levetiracetam using capillary electrochromatography"
D. Mangelings, J. Saevels, Y. Vander Heyden
Journal of Separation Science 29 (2006) 2827-2836.
- 18. "Control of electroosmotic flow by a cation additive to enhance
the separation of amino acids by micellar electrokinetic chromatography"
Q. Qu, X. Tang, D. Mangelings, C. Wang, G. Yang, X. Hu, C. Yan
Journal of Chromatography B 853 (2007) 31-37.
- 19. "High-throughput screening and optimization approaches for chiral compounds by means of microfluidic devices" (review article)
D. Mangelings and Y. Vander Heyden
Combinatorial Chemistry & High Throughput Screening 10 (2007) 317-325.
- 20. "Pressurized capillary electrochromatographic assay of trimethoprim impurities using 1 µm particle-based columns"
Q. Qu, D. Mangelings, F. Shen, X. Hu, C. Yan, Y. Zhang, Y. Vander Heyden
Journal of Chromatography A 1169 (2007) 228-234.
- 21. "Evaluation of polymeric methacrylate-based monoliths in capillary electrochromatography:
potential for pharmaceutical applications"
D. Mangelings, I. Tanret, V. Meert, S. Eeltink, P. Schoenmakers, W. Th. Kok, Y. Vander Heyden
Journal of Chromatographic Science 45 (2007) 578-586.
- 22. "Reversed-phase column selection for pharmaceutical and compendial analysis: an overview"
D. Mangelings Y. Vander Heyden
Published on www.chromedia.nl: Home --> LC basics --> RPLC, Normal Phase,Chiral Chromatography and more --> Reversed Phase (RPLC)
- 23. "Chiral separations in sub- and supercritical fluid chromatography" (review article)
D. Mangelings and Y. Vander Heyden
Journal of Separation Science 31 (2008) 1252-1273.
- 24"Method development for HILIC assays" (review article)
B. Dejaegher, D. Mangelings, Y. Vander Heyden
Journal of Separation Science 31 (2008) 1438-1448.
- 25. "Influence of the polymerization-mixture composition for monolithic methacrylate-based
columns on the electrochromatographic performance of drug molecules"
I. Tanret, D. Mangelings, Y. Vander Heyden
Journal of Pharmaceutical and Biomedical Analysis 48 (2008) 264-277.
- 26. "Fast Generic Chiral Separation Strategies using Electrophoretic and Liquid Chromatographic Techniques"
H. Ates, D. Mangelings, Y. Vander Heyden
Journal of Pharmaceutical and Biomedical Analysis 48 (2008) 288-294.
- 27. "Chiral Separations in Polar Organic Solvent Chromatography: Updating a
Screening Strategy with New Chlorine-containing Polysaccharide-Based Selectors"
H. Ates, D. Mangelings, Y. Vander Heyden
Journal of Chromatography B 875 (2008) 57-64.
- 28. "Pressure-assisted Capillary Electrochromatography versus Capillary Electrochromatography using methacrylate-based
monolithic columns: influence of the polymerization-mixture composition"
I. Tanret, D. Mangelings, Y. Vander Heyden
Electrophoresis 29 (2008) 4463-4474.
- 29. "Monolithic silica xerogel capillary column for separations in capillary LC and pressurized capillary electrochromatography"
Q.-S. Qu, S. Wang, D. Mangelings, C.-Y. Wang, G.-J. Yang, X.-Y. Hu, C. Yan
Electrophoresis 30 (2009) 1071-1076.
- 30. "Detection systems for microfluidic devices with a major focus on pharmaceutical and chiral analysis"
I. Tanret, D. Mangelings, Y. Vander Heyden
Current Pharmaceutical Analysis 5 (2009) 101-111.
- 31. "Monolithic stationary phases in classic and chiral pharmaceutical analysis with CEC and pCEC"
I. Tanret, D. Mangelings, Y. Vander Heyden
Journal of Chromatographic Science 47 (2009) 407-417.
- 32. "Monolithic silica capillary columns with immobilized cellulose tris(3,5-dimethylphenyl-carbamate)
for enantiomer separations in capillary electrochromatography"
C. He, A. Hendrickx, D. Mangelings, J. Smeyers-Verbeke, Y. Vander Heyden
Electrophoresis 30 (2009) 3796-3803.
- 33. "Sillica Spheres Coated with C18 Modified Gold Nanoparticles for Capillary Liquid
Chromatographic and Pressurized Capillary Electrochromatographic Separations"
Q. Qu, S. Peng, D. Mangelings, X. Hu, C. Yan
Electrophoresis 31 (2010) 556-562.
- 34. "Fingerprint development for Ginkgo biloba extracts by pressurized
capillary electrochromatography: comparison of column types"
J. Wang, D. Mangelings, G. Fan, Y. Wu, Y. Vander Heyden
Journal of Chromatographic Science 48 (2010) 428-435.
- 35."Microfluidics in macro-biomolecules analysis: Macro inside in a nano world"
I. Oita, H. Halewyck, B. Thys, B. Rombaut, Y. Vander Heyden, D. Mangelings
Analytical and Bioanalytical Chemistry 398 (2010) 239–264.
- 36."Enantioseparations of pharmaceuticals with chlorinated and non-chlorinated polysaccharide-based
stationary phases in capillary electrochromatography"
A. Hendrickx, D. Mangelings, B. Chankvetadze, Y. Vander Heyden
Electrophoresis 31 (2010) 3207-3216.
- 37."Permanent gold nanoparticle coatings on polyelectrolyte multilayers modified
capillaries for open-tubular capillary electrochromatography"
Q. Qu, D. Liu, D. Mangelings, C. Yang, X. Hua
Journal of Chromatography A 1217 (2010) 6588-6594.
- 38."Pressurized capillary electrochromatography in a screening for possible antioxidant
molecules in Mallotus fingerprints: Challenges, potentials and prospects"
S. Pieters, C. Tistaert, G. Alaerts, K. Bodzioch, D. Mangelings, B. Dejaegher,
C. Rivičre, N. Nguyen Hoai, M. Chau Van, J. Quetin-Leclerq, Y. Vander Heyden
Talanta 83 (2011) 1188-1197.
- 39."Facile synthesis and size control of highly monodispersed hybrid silica spheres
through a novel nuclei controlling method"
Q. Qu, P. Xu, D. Mangelings, C. Yang, X. Hu
Journal of Non-crystalline Solids 357 (2011) 976–980.
- 40."Chiral Separation in Normal-Phase Liquid Chromatography:
Enantioselectivity of recently Commercialized Polysaccharide-Based Selectors Part I. Enantioselectivity under generic screening conditions"
A. A Younes, D. Mangelings, Y. Vander Heyden
Journal of Pharmaceutical and Biomedical Analysis 55 (2011) 414–423.
- 41."Capillary methods for drug analysis"
A. Hendrickx, D. Mangelings, Y. Vander Heyden
Journal of AOAC International 94 (2011) 667-702.
- 42."Chiral separations in normal phase liquid chromatography: Use of new chlorine-containing
polysaccharide selectors. Part II: Optimisation strategy"
A. A. Younes, D. Mangelings, Y. Vander Heyden
Journal of Pharmaceutical and Biomedical Analysis 56 (2011) 521-537.
- 43."Optimizing the separation of acetylsalicylic acid from some of its impurities in CEC on monolithic capillary columns"
I. Tanret, D. Mangelings, Y. Vander Heyden
Journal of Separation Science 34 (2011) 2284-2292.
- 44."Capillary electrochromatographic testing of monolithic silica columns synthesized according
to an experimental design approach"
X. Wu, D. Mangelings, I. Oita, I. Tanret, C. Yan, Y. Vander Heyden
Journal of Separation Science 34 (2011) 2305-2313.
- 45."Enantioselective capillary electrochromatography: recent developments and new trends"
D. Mangelings, Y. Vander Heyden
Electrophoresis 32 (2011) 2583–2601.
- 46."Evaluation of the enantioselectivity of monolithic stationary phases immobilized with different
concentrations of cellulose tris(3,5-dimethylphenyl-carbamate), analyzed with different mobile phases in capillary electrochromatography"
C. Lv, D. Mangelings, Y. Vander Heyden
Electrophoresis 32 (2011) 2708-2717.
- 47."Updating a chiral separation strategy for non-acidic drugs with capillary electrochromatography applicable
for both chlorinated and non-chlorinated polysaccharide selectors"
A. Hendrickx, D. Mangelings, B. Chankvetadze, Y. Vander Heyden
Electrophoresis 32 (2011) 2718-2726.
- 48."Integrated waveguide structure for highly sensitive
THz spectroscopy of nano-liter liquids in capillary tubes"
V. Matvejev, C. de Tandt, W. Ranson, J. Stiens, R. Vounckx, D. Mangelings
Progress In Electromagnetics Research 121 (2011) 89-101.
- 49."Combined use of isopropylamine and trifluoroacetic acid in methanol-containing
mobile phases for chiral supercritical fluid chromatography"
K. De Klerck,D. Mangelings, D. Clicq, F. De Boever, Y. Vander Heyden
Journal of Chromatography A 1234 (2012) 72-79.
- 50."Supercritical fluid chromatography for the enantioseparation of pharmaceuticals"
K. De Klerck,D. Mangelings, Y. Vander Heyden
Journal of Pharmaceutical and Biomedical Analysis, in press.
- 51."Amylose 3,5-dimethylphenylcarbamate immobilized on monolithic silica stationary
phases for chiral separations in capillary electrochromatography"
Y. Liu, Y. Vander Heyden, D. Mangelings
Electrophoresis, accepted.
Terug naar boven
Oral Presentations
- 1. "Chiral separations with capillary electrochromatography"
Meeting with Chiral Technologies, 25 September 2003, VUB-Jette-Belgium
- 2. "Chiral separations by means of capillary electrochromatography: Progress and future developments"
Meeting with Sanofi Synthelabo, 22 April 2003, VUB-Jette-Belgium
- 3. "Screening strategy in capillary electrochromatography for chiral pharmaceuticals using
polysaccharide stationary phases"
D. Mangelings, N. Hardies, M. Maftouh, C. Suteu, D.L. Massart and Y. Vander Heyden
11th Forum of Pharmaceutical Sciences, 8-9 May 2003, Spa-Belgium
- 4. "Capillary electrochromatography: Differences between normal- and reversed-phase stationary phases
and future work"
Meeting with Sanofi Synthelabo, 16 December 2003, VUB-Jette-Belgium
- 5. "Chiral screening strategy in capillary electrochromatography for acidic substances"
Meeting with Sanofi Synthelabo, 08 July 2004, VUB-Jette-Belgium
- 6. "Chiral separation strategy in capillary electrochromatography: Finalization"
Meeting with Sanofi Synthelabo, 25 March 2005, VUB-Jette-Belgium
- 7. "Generic separation strategies in chiral CEC: where are we and what could be the future?"
D. Mangelings, M. Maftouh, Y. Vander Heyden
AFSEP symposium, 7 April 2005, Paris, France
- 8. "Capillary Electrochromatographic Screening and
Optimization Strategies for Chiral Method Development"
D. Mangelings, M. Maftouh, D.L. Massart, Y. Vander Heyden
HPLC 2005: 29th International Symposium on High Performance Liquid Phase Separations and Related Techniques,
26-30 June 2005, Stockholm International Fairs-Stockholm-Sweden
- 9. "Evaluation of Capillary Electrochromatography as Chiral Separation Technique-Definition of a Chiral Separation Strategy"
D. Mangelings, M. Maftouh, Y. Vander Heyden
Drug Analysis 2006, 16-19 May 2006, University of Namur-Namur-Belgium
- 10. "Evaluation of Capillary Electrochromatography as Chiral Separation Technique-Definition of a Chiral Separation Strategy"
D. Mangelings, M. Maftouh, Y. Vander Heyden
The Jubilee XXXth Symposium, 12-14 June 2006, Szczyrk-Poland
- 11. "Evaluation of Capillary Electrochromatography as Chiral Separation Technique. Definition of a Chiral Separation Strategy"
D. Mangelings, M. Maftouh, Y. Vander Heyden
2nd Joint CE User Meeting KVCV – KNCV, 17 November 2006, Grobbendonk, Belgium
- 12. "Evaluation of Capillary Electrochromatography as Chiral Separation Technique-Definition of a Chiral Separation Strategy"
D. Mangelings
Algemene Vergadering van het Belgisch Genootschap voor Farmaceutische Wetenschappen,
22 March 2007, Johnson & Johnson, Beerse-Belgium
- 13. "Evaluation of methacrylate-ester based monoliths for pharmaceutical analysis using capillary electrochromatographic
methods"
D. Mangelings, I. Tanret, Y. Vander Heyden
HPLC 2007: 31st International Symposium on High-Performance Liquid Phase Separations and Related Techniques,
17-21 June 2007, International Convention Center-Ghent-Belgium
- 14. "Definition of Generic Chiral Separation Strategies for Pharmaceutical Compounds
using Liquid Chromatographic Techniques"
D. Mangelings, H. Ates, N. Matthijs, Y. Vander Heyden
RDPA 2007: 12th International Meeting on Recent Developments in Pharmaceutical Analysis,
23-26 September 2007, Elba, Italy
- 15. "Separation of Chiral Drug Compounds on New Polysaccharide Based Chiral Stationary Phases in Polar
Organic Solvent Chromatography"
H. Ates, D. Mangelings, Y. Vander Heyden
13th Forum of Pharmaceutical Sciences, 11-12 October 2007, Spa, Belgium
- 16. "Methacrylate-based monolithic columns in capillary electrochromatography: improving
the separation performance by varying the polymerization-mixture composition"
I. Tanret, D. Mangelings, Y. Vander Heyden
13th Forum of Pharmaceutical Sciences, 11-12 October 2007, Spa, Belgium
- 17. "Definition of a chiral separation strategy in capillary electrochromatography and application to a
pharmaceutical formulation"
D. Mangelings, M. Maftouh, J. Saevels , Y. Vander Heyden
ISCD 20-20th International Symposium on Chirality, 6-9 July 2008, Geneva, Switzerland
- 18. "Methacrylate-based monolithic columns in (pressurized) capillary
electrochromatography: investigating the polymerization mixture composition"
I. Tanret, D. Mangelings, Y. Vander Heyden
CEEPUS International Symposium and Summer School on Bioanalysis, 1-10 June 2008, Nitra, Slovakia
- 19. "Methacrylate-based monolithic columns in (pressurized) capillary
electrochromatography: investigating the polymerization mixture composition"
I. Tanret, D. Mangelings, Y. Vander Heyden
ITP 2008: International Symposium on Capillary Electroseparation Techniques, 31 August – 4 September 2008,
Catania, Italy.
- 20. "An overview of chiral selectors and separation mechanisms in HPLC and CE"
Y. Vander Heyden, D. Mangelings
Invited lecture at the Symposium "Best practice of chiral separations in pharmaceutical
development" at Pittcon2009, 8-13 March 2009, Chicago, Illinois, USA, .
- 21. "Discovering the miniature world of microfluidics"
I. Tanret, D. Mangelings, A. Gaspar, Y. Vander Heyden
14th Forum of Pharmaceutical Sciences, 14-15 May 2009, Blankenberge, Belgium.
- 22. "Performance comparison of chlorine-containing and non-chlorine containing polysaccharide-based selectors for chiral separations"
H. Ates, D. Mangelings, Y. Vander Heyden
14th Forum of Pharmaceutical Sciences, 14-15 May 2009, Blankenberge, Belgium.
- 23. "Bioassay guided isolation of antiplasmodial constituents from Ormocarpum kirkii"
L. Dhooghe, S. Maregesi, D. Mangelings, Y. Vander Heyden, L. Maes, P. Cos, S. Apers, A. Vlietinck, L. Pieters
14th Forum of Pharmaceutical Sciences, 14-15 May 2009, Blankenberge, Belgium.
- 24. "Pressurized capillary electrochromatography as an alternative technique to high-performance liquid chromatography for the
indication of active compounds in mallotus species"
S. Pieters, K. Bodzioch, C. Tistaert, G. Alaerts, B. Dejaegher, D. Mangelings, Y. Vander Heyden
14th Forum of Pharmaceutical Sciences, 14-15 May 2009, Blankenberge, Belgium.
- 25. "Chlorine-Containing Polysaccharide-Based Stationary Phases in Chiral Liquid Chromatography"
H. Ates, D. Mangelings, J. Smeyers-Verbeke, Y. Vander Heyden
Dag van het Farmaceutisch Onderzoek, 2 June 2009, Mechelen, Belgium.
- 26. "Methacrylate-based monolithic columns in CEC: the separation of acetylsalicylic acid from its impurities "
I. Tanret, D. Mangelings, J. Smeyers-Verbeke, Y. Vander Heyden
Dag van het Farmaceutisch Onderzoek, 2 June 2009, Mechelen, Belgium.
- 27. "Combining methacrylate-based monolithic separation potential with microfluidic
lab-on-a-chip technology: A novel approach"
I. Tanret, A.Gáspár, D. Mangelings, Y. Vander Heyden
5th conference by the Nordic Separation Science Society (NoSSS), 26-29 Augustus 2009, Tallinn, Estonia.
- 28. "Use of Chlorinated polysaccharide-based chiral stationary phases to update generic
separation strategies for capillary electrochromatography"
A. Hendrickx, D. Mangelings, B. Chankvetadze, Y. Vander Heyden
The XXXIIIrd Symposium: Chromatographic methods of investigating the organic compounds,
25-27 May 2010, Szczyrk-Poland
- 29. "Evaluation of methacrylate-based monolithic stationary phases for the analysis of drug molecules in the capillary format"
I. Tanret, D. Mangelings, Y. Vander Heyden
The XXXIIIrd Symposium: Chromatographic methods of investigating the organic compounds,
25-27 May 2010, Szczyrk-Poland
- 30. "Polysaccharide-Type Chiral Selectors: The Impact of Chlorine-Containing Groups on
Enantioselectivity in Polar Organic Solvent Chromatography"
H. Ates, D. Mangelings, Y. Vander Heyden
ISC-2010, 28th International Symposium on Chromatography, 12-16 September 2010, Valencia, Spain
- 31. "Polysaccharide-Type Chiral Selectors: The Impact of Chlorine-Containing Groups on
Enantioselectivity in Polar Organic Solvent Chromatography"
H. Ates, D. Mangelings, Y. Vander Heyden
DA-2010, Drug Analysis 2010, 21-24 September 2010, Antwerp, Belgium
- 32. "Update of a chiral separation strategy for non-acidic drugs with capillary electrochromatography"
A. Hendrickx, D. Mangelings, Y. Vander Heyden
PhD day Research Unlimited, 5 April 2011, VUB-Jette, Brussels, Belgium
- 33. "A chiral separation strategy for non-acidic drugs with capillary electrochromatography"
A. Hendrickx, D. Mangelings, Y. Vander Heyden
15th Forum of Pharmaceutical Sciences, 12-13 May 2011, Spa, Belgium
- 34. "Updating a screening strategy for chiral separations in supercritical
fluid chromatography with new chlorinated polysaccharide-based selectors"
K. De Klerck, G. Parewyck, D. Mangelings, Y. Vander Heyden
15th Forum of Pharmaceutical Sciences, 12-13 May 2011, Spa, Belgium
- 35. "Update of Generic Chiral Separation Strategies for Pharmaceutical Compounds
using Chromatographic and Electrophoretic Techniques"
D. Mangelings, H. Ates, K. De Klerck, A. Hendrickx, A. Younes, Y. Vander Heyden
The XXXIVth Symposium: Chromatographic methods of investigating the organic compounds, 8-10 June 2011, Szczyrk-Poland
- 36. "Update of Generic Chiral Separation Strategies for Pharmaceutical Compounds
using Chromatographic and Electrophoretic Techniques"
D. Mangelings, H. Ates, K. De Klerck, A. Hendrickx, A. Younes, Y. Vander Heyden
ISCD 23: 23rd International Symposium on Chirality (Chirality 2011), 10-13 July 2011, Liverpool, United Kingdom
- 37. "Test set reductions in the development of chiral separation strategies in polar organic solvent chromatography"
H. Ates, B. Desmedt, D. Mangelings, Y. Vander Heyden
ISCD 23: 23rd International Symposium on Chirality (Chirality 2011), 10-13 July 2011, Liverpool, United Kingdom
- 38. "Update of a chiral separation strategy for non-acidic drugs with capillary electrochromatography
using chlorinated and non-chlorinated polysaccharide selectors"
A. Hendrickx, D. Mangelings, B. Chankvetadze, Y. Vander Heyden
ISCD 23: 23rd International Symposium on Chirality (Chirality 2011), 10-13 July 2011, Liverpool, United Kingdom
- 39. "Chiral Separation Strategies for Pharmaceutical Compounds
using Chromatographic and Electrophoretic Techniques"
D. Mangelings, H. Ates, K. De Klerck, A. Hendrickx, A. Younes, Y. Vander Heyden
ITP 2011: 18th International Symposium on Electr- and Liquid
phase-separation Techniques, 28-31 August 2011, Tbilisi, Georgia
- 40. "Separations in Normal Phase Liquid Chromatography: Separation Strategy Update Using Recently
Introduced Polysaccharide-based Chiral Stationary Phases"
A.A. Younes, D. Mangelings, Y. Vander Heyden
PhD day Research Unlimited, 27 March 2012, VUB-Jette, Brussel, België
Terug naar boven
Poster Presentations
- 1. "Chromatographic screening strategies for chiral pharmaceuticals implemented in
a Knowledge-Based System (KBS) : RPLC and NPLC"
N. Matthijs, C. Perrin, D. Mangelings, D.L. Massart, Y. Vander Heyden
ChemoAC Meeting, 7-8 November 2001, VUB - Jette - Belgium
- 2. "Enantioseparations of basic compounds using cyclodextrins: Comparison of Capillary Electrophoresis and
Capillary Electrochromatography"
D. Mangelings, C. Perrin, D.L. Massart, Y. Vander Heyden
Drug Analysis 2002, 22-23 april 2002, Bruges-Belgium
ChemoAC Meeting, 24-25 April 2002, VUB-Jette-Belgium
- 3. "Experimental design optimization of the chiral separation of chlorthalidone by Capillary Electrochromatography using
an achiral stationary phase and cyclodextrin in the mobile phase"
D. Mangelings, C. Perrin, Y. Vander Heyden
ChemoAC Meeting, 21-22 November 2002, VUB-Jette-Belgium
- 4. "Screening strategy in capillary electrochromatography using polysaccharide stationary phases"
D. Mangelings, N. Hardies, M. Maftouh, C. Suteu, Y. Vander Heyden
ChemoAC Meeting, 26 March 2003, VUB-Jette-Belgium
- 5. "Screening strategy in capillary electrochromatography for chiral pharmaceuticals using polysaccharide
stationary phases"
D. Mangelings, N. Hardies, M. Maftouh, C. Suteu, D.L. Massart, Y. Vander Heyden
HPLC 2003: 27th Symposium on High Performance Liquid Phase Separations and Related Techniques,
15-19 June 2003, Nice-France
- 6. "Screening strategy in capillary electrochromatography for chiral pharmaceuticals using
polysaccharide stationary phases"
D. Mangelings, N. Hardies, M. Maftouh, C. Suteu, D.L. Massart, Y. Vander Heyden
KVCV Symposium, Fifth Belgian CE-users Group Meeting, CE-MS in Pharmaceutical Development and
Medical Protein Research, 16 October 2003, Janssen Pharmaceutica, Beerse, Belgium
- 7. "Investigating differences between normal-phase and reversed-phase
chiral stationary phases with capillary electrochromatography"
D. Mangelings, M. Maftouh, D.L. Massart and Y. Vander Heyden
ChemoAC Meeting, 15-16 January 2004, VUB-Jette-Belgium
- 8. "Differences between normal-phase and reversed-phase polysaccharide
chiral stationary phases in capillary electrochromatographic separations"
D. Mangelings, M. Maftouh, D.L. Massart and Y. Vander Heyden
HPCE 2004: 17th International Symposium on Microscale Separations and Capillary Electrophoresis,
8-12 February 2004, Salzburg-Austria
- 9. "Defining a screening approach to evaluate the enantioselectivity of
acidic drugs in capillary electrochromatography on polysaccharide stationary phases"
D. Mangelings, M. Maftouh, D.L. Massart and Y. Vander Heyden
PBA 2004: 15th International Symposium on Pharmaceutical and Biomedical Analysis, 2-6 May 2004, Florence-Italy
- 10. "Screening approach in capillary electrochromatography for the enantioseparation of acidic pharmaceuticals on
polysaccharide stationary phases"
D. Mangelings, I. Tanret, M. Maftouh, D.L. Massart and Y. Vander Heyden
ChemoAC Meeting, 10-11 June 2004, VUB-Jette-Belgium
- 11. "Screening approach in capillary electrochromatography to evaluate the enantioselectivity
of acidic drugs on polysaccharide stationary phases"
D. Mangelings, N. Matthijs, M. Maftouh, D.L. Massart and Y. Vander Heyden
ISCD-16: 16th International Symposium on Chirality, 11-14 July 2004, New York-USA
- 12. "Development of a screening strategy in capillary electrochromatography to evaluate the enantioselectivity
of acidic drugs on polysaccharide stationary phases"
D. Mangelings, Y. Vander Heyden, I. Tanret, M. Maftouh and D.L. Massart
ISC-04: 25th International Symposium on Chromatography, 4-8 October 2004, Paris-France
- 13. "Application of a chiral separation strategy in capillary
electrochromatography for basic, bifunctional and neutral compounds"
D. Mangelings, J. Discry and M. Maftouh
ChemoAC Meeting, 9-10 December 2004, VUB-Jette-Belgium
- 14. "Polar organic mode-based chromatographic chiral screening strategy on polysaccharide columns"
Y. Vander Heyden, N. Matthijs, D. Mangelings, M. Maftouh, D.L. Massart
29th symposium ‘Chromatographic methods of investigating the organic compounds’,
8-10 June 2005, Katowice-Szczyrk, Poland
- 15. "Screening and Optimization Strategies in Chiral Method
Development by means of Capillary Electrochromatography and Future Perspectives"
D. Mangelings, M. Maftouh
ChemoAC Meeting, 16-17 June 2005, VUB-Jette-Belgium
- 16. "Polar organic mode-based chromatographic chiral screening strategy on polysaccharide columns"
Y. Vander Heyden, N. Matthijs, D. Mangelings, M. Maftouh, D.L. Massart
HPLC 2005: 29th International Symposium on High Performance Liquid Phase Separations
and Related Techniques, 26-30 June 2005, Stockholm, Sweden
- 17. "Separation of chiral drug compounds on new polysaccharide-based stationary phases"
H. Ates, D. Mangelings, Y. Vander Heyden
The jubilee XXXIth Symposium chromatographic methods of investigating the organic compounds,
4-6 June 2007, Szczyrk-Poland
- 18. "Influence of the polymerization mixture composition on the separation performance of
methacrylate-ester-based monolithic columns in capillary electrochromatography"
I. Tanret, D. Mangelings, Y. Vander Heyden
The jubilee XXXIth Symposium chromatographic methods of investigating the organic compounds,
4-6 June 2007, Szczyrk-Poland
- 19. "Separation of chiral drug compounds on new polysaccharide-based stationary phases"
H. Ates, D. Mangelings, Y. Vander Heyden
HPLC 2007: 31st International Symposium on High-Performance Liquid Phase Separations and Related Techniques,
17-21 June 2007, International Convention Center-Ghent-Belgium
- 20. "Influence of the polymerization mixture composition on the chromatographic performance of
methacrylate-ester-based monolithic columns in capillary electrochromatography "
I. Tanret, D. Mangelings, Y. Vander Heyden
HPLC 2007: 31st International Symposium on High-Performance Liquid Phase Separations and Related Techniques,
17-21 June 2007, International Convention Center-Ghent-Belgium
- 21. "Evaluation of Methacrylate-ester Based Monoliths for
Pharmaceutical Analysis Using Capillary Electrochromatographic Methods"
D. Mangelings, I. Tanret, Y. Vander Heyden
RDPA 2007: 12th International Meeting on Recent Developments in Pharmaceutical Analysis,
23-26 September 2007, Elba, Italy
- 22. "(Bio)-Farmaceutische analyse, geďntegreerd practicum"
D. Mangelings, S. Sarre, K. De Paepe, A. Foriers, Y. Vander Heyden
Nederlands-Vlaamse Farmacie Onderwijsdag, 25 May 2009, Universiteit Utrecht, Netherlands
- 23. "Updating and evaluating screening strategies for chiral drug substances using new chlorinated polysaccharide-based stationary phases by means of
polar organic solvent chromatography"
H. Ates, D. Mangelings, Y. Vander Heyden
ISCD 20: 20th International Symposium on Chirality, 6-9 July 2008, Geneva, Switzerland
- 24. "Screening for antioxidant compounds in pressurized capillary electrochromatography fingerprints
from Mallotus species using partial least squares algorithms"
S. Pieters, K. Bodzioch, C. Tistaert, G. Alaerts, B. Dejaegher, D. Mangelings, Y. Vander Heyden
25th Symposium on Chemometrics, 28 May 2009, Delft, Netherlands
- 25. "New Chlorine-Containing Selectors for High-Throughput Screening of Chiral Drug
Compounds Tested in Polar Organic Solvent Chromatography "
H. Ates,D. Mangelings, J. Smeyers-Verbeke, Y. Vander Heyden
34th International Symposium on High-Performance Liquid Phase
Separations and Related Techniques, 28 June – 2 July 2009, Dresden, Germany
- 26. "Methacrylate-based monolithic columns in CEC: The separation of acetylsalicylic acid from its impurities"
I. Tanret, D. Mangelings, Y. Vander Heyden
5th conference by the Nordic Separation Science Society (NoSSS), 26-29 Augustus 2009, Tallinn, Estland
- 27. "Evaluation of new types of chiral stationary phases tested in capillary electrochromatography"
A. Hendrickx, D. Mangelings, B. Chankvetadze, Y. Vander Heyden
RDPA 2009: 13th international meeting on Recent Developments in Pharmaceutical Analysis, 9-12 September 2009, Milan, Italy
- 28. "Pressurized capillary electrochromatography, a useful technique to screen for antioxidant compounds in mallotus fingerprints?"
S. Pieters, K. Bodzioch, C. Tistaert, G. Alaerts, B. Dejaegher, D. Mangelings, Y. Vander Heyden
RDPA 2009: 13th international meeting on Recent Developments in Pharmaceutical Analysis, 9-12 September 2009, Milan, Italy
- 29. "Chiral Separations in Normal Phase Liquid Chromatography: Enantioselectivity of Recently Commercialized Polysaccharide-Based
Chiral Selectors Part I: Enantioselectivity at Screening Conditions”"
A.A. Younes, D. Mangelings, Y. Vander Heyden
PhD Research Day – 28 May 2010 - VUB - Brussels – Belgium
- 30. "Comparative enantioseparations of pharmaceuticals in capillary electrochromatography on polysaccharide-based chiral
stationary phases containing selectors with or without chlorinated derivatives"
A. Hendrickx, D. Mangelings, B. Chankvetadze, Y. Vander Heyden
ISC-2010, 28th International Symposium on Chromatography, 12-16 September 2010, Valencia, Spain
- 31. "Evaluation of methacrylate-based monolithic stationary phases for the analysis of drug molecules in capillary format"
D. Mangelings, I. Tanret, Y. Vander Heyden
DA-2010, Drug Analysis 2010, 21-24 september 2010, Antwerp, Belgium
- 32. "Comparative enantioseparations of pharmaceuticals in capillary electrochromatography on polysaccharide-based chiral
stationary phases containing selectors with or without chlorinated derivatives"
A. Hendrickx, D. Mangelings, B. Chankvetadze, Y. Vander Heyden
DA-2010, Drug Analysis 2010, 21-24 september 2010, Antwerp, Belgium
- 33. "Chiral Separations in Normal Phase Liquid Chromatography: Enantioselectivity of Recently Commercialized
Polysaccharide-Based Chiral Selectors Part I: Enantioselectivity at screening conditions"
A.A. Younes, D. Mangelings, Y. Vander Heyden
DA-2010, Drug Analysis 2010, 21-24 september 2010, Antwerp, Belgium
- 34. "Updating a screening strategy for chiral separations in supercritical
fluid chromatography with new chlorinated polysaccharide-based selectors"
K. De Klerck, G. Parewyck, D. Mangelings, Y. Vander Heyden
PhD day Research Unlimited, 5 April 2011, VUB-Jette, Brussels, Belgium
- 35. "Chiral Separations in Normal Phase Liquid Chromatography: Enantioselectivity of Recently Commercialized Polysaccharide-Based
Chiral Selectors Part II: Enantioselectivity at Optimization Conditions"
A.A. Younes, D. Mangelings, Y. Vander Heyden
PhD day Research Unlimited, 5 April 2011, VUB-Jette, Brussels, Belgium
- 36. "Updating a screening strategy for chiral separations in supercritical
fluid chromatography with new chlorinated polysaccharide-based selectors"
K. De Klerck, G. Parewyck, D. Mangelings, Y. Vander Heyden
The XXXIVth Symposium: Chromatographic methods of investigating the organic compounds, 8-10 June 2011, Szczyrk-Poland
- 37. "Chiral Separations in Normal Phase Liquid Chromatography: Enantioselectivity of Recently Commercialized Polysaccharide-Based
Chiral Selectors Part II: Enantioselectivity at Optimization Conditions"
A.A. Younes, D. Mangelings, Y. Vander Heyden
The XXXIVth Symposium: Chromatographic methods of investigating the organic compounds, 8-10 June 2011, Szczyrk-Poland
- 38. "Updating a generic chiral screening step in supercritical fluid chromatography
with new mobile phases and chlorinated polysaccharide-based selectors"
K. De Klerck, G. Parewyck, D. Mangelings, Y. Vander Heyden
ISCD 23: 23rd International Symposium on Chirality (Chirality 2011), 10-13 July 2011, Liverpool, United Kingdom
- 39. "THz Excess Absorption by nL-volume water-alcohol mixtures: model and experimental verification"
V. Matvejev, C. De Tandt, W. Ranson, D. Mangelings, M. Zizi, J. Stiens
International Forum on Terahertz Spectroscopy and Imaging, 7-8 March 2012, Kaiserslautern, Germany
- 40. "Fused-core stationary phases for fingerprint development of Phyllanthus and Mallotus species"
G. Parewyck, C. Tistaert, B. Dejaegher, D. Mangelings, Yvan Vander Heyden
PhD day Research Unlimited, 27 March 2012, VUB-Jette, Brussel, België
- 41. "Updating a generic chiral screening step in supercritical fluid
chromatography with new chlorinated polysaccharide-based selectors"
K. De Klerck, G. Parewyck, D. Mangelings, Y. Vander Heyden
PhD day Research Unlimited, 27 March 2012, VUB-Jette, Brussel, België
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Memberships
- Belgisch Genootschap voor Farmaceutische Wetenschappen (Belgian Society of Pharmaceutical Sciences) (BGFW)
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Prizes
- February 2004: Applied Physical Chemistry Award for outstanding achievements in the field of chromatography of
the Istvan Halasz Foundation, obtained at HPCE 2004 (Salzburg, Austria)
- February 2007: Laureate of the National Prize of the
Belgian Society of Pharmaceutical Sciences
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Coordinates
Vrije Universiteit Brussel
Faculteit Geneeskunde en Farmacie
Farmaceutisch instituut
Vakgroep Analytische Scheikunde en Farmaceutische Technologie
Laarbeeklaan 103
B-1090 Brussels Belgium
Tel: (+32) 2 477 43 29
Fax: (+32) 2 477 47 35
Email: debby.mangelings@vub.ac.be
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