Vrije Universiteit Brussel


Research Page of Christophe Tistaert

Last update: 22/01/2012

General Information

CIVIL STATUS :

  • Born March 28th 1984
  • Belgian

EDUCATION :

  • July 2007:
    Master in Pharmaceutical sciences obtained at the Katholieke Universiteit Leuven (KUL) - Belgium

  • Since October 2007:
    Ph.D. Student in Pharmaceutical Sciences at the Department of Analytical Chemistry and Pharmaceutical Technology

RESEARCH TOPICS :

  • Analytical Chemistry:
    - Fingerprint chromatography
    - Orthogonal chromatographic systems
    - Mass spectrometry
    - Near-infrared spectroscopy

  • Chemometrics:
    - Multivariate calibration
    - Classification and discrimination
    - Exploratory analysis
    - Alignment of complex chromatographic fingerprints
    - Multivariate Curve Resolution - Alternating Least Squares (MCR-ALS)
    - (pre-)treatment of chromatographic fingerprints

Stays abroad

  • September 2010 - December 2010
    Virginia Commonwealth University
    Department of Chemistry (Prof. Sarah C. Rutan)
    Project: Resolution of spectrally rank deficient MCR-ALS components in 2D-LC-DAD analysis

Publications

  • /1/ Potential antioxidant compounds in Mallotus species fingerprints. Part I: Indication, using linear multivariate calibration techniques
    C. Tistaert, B. Dejaegher, N. Nguyen Hoai, G. Chataigné, C. Rivière, V. Nguyen Thi Hong, M. Chau Van, J. Quetin-Leclerq, Y. Vander Heyden
    Analytica Chimica Acta 652 (2009) 189-197

  • /2/ Dissimilar chromatographic systems to indicate and identify compounds potentially responsible for the antioxidant activity of Mallotus species
    C. Tistaert, B. Dejaegher, P. Doan Lan, C. Rivière, M. Chau Van, J. Quetin-Leclerq, Y. Vander Heyden
    Talanta 83 (2011) 1198-1208

  • /3/ Quality control of Citri reticulatae pericarpium: exploratory analysis and discrimination
    C. Tistaert, L. Thierry, A. Szandrach, G. Fan, M. Frédérich, Y. Vander Heyden
    Analytica Chimca Acta 705 (2011) 111-122

  • /4/ Chromatographic separation techniques and data handling methods for herbal fingerprints: a review
    C. Tistaert, B. Dejaegher, Y. Vander Heyden
    Analytica Chimica Acta 690 (2011) 148-161

  • /5/ Resolution of spectrally rank deficient MCR-ALS components in 2D-LC-DAD analysis
    C. Tistaert, Y. Vander Heyden, S. C. Rutan
    Accepted for publication in Journal of Chemometrics

  • /6/ Potential antioxidant compounds in Mallotus species fingerprints. Part II: Fingerprint alignment, data analysis and peak identification
    C. Tistaert, B. Dejaegher, N. Nguyen Hoai, G. Chataigné, C. Rivière, V. Nguyen Thi Hong, M. Chau Van, J. Quetin-Leclerq, Y. Vander Heyden
    Accepted for publication in Analytica Chimica Acta

  • /7/Development of HPLC fingerprints for Mallotus species extracts and evaluation of the peaks responsible for their antioxidant activity
    N. Nguyen Hoai, B. Dejaegher, C. Tistaert, V. Nguyen Thi Hong, C. Rivière, M. Chau Van, J. Quetin-Leclerq, Y. Vander Heyden
    Journal of Pharmaceutical and Biomedical Analysis 50 (2009) 753-763

  • /8/ Mallotus species from Vietnamese mountainous areas: phytochemistry and pharmacological activities
    C. Rivière, V. Nguyen Thi Hong, Q. Tran Hong, G. Chataigné, N. Nguyen Hoai, B. Dejaegher, C. Tistaert, T. Nguyen Thi Kim, Y. Vander Heyden, M. Chau Van, J. Quetin-Leclercq
    Phytochemistry Reviews 9 (2010) 217-253

  • /9/ Pressurized capillary electrochromatography in a screening for possible antioxidant molecules in Mallotus fingerprints: Challenges, potentials, and prospects
    S. Pieters, C. Tistaert , K. Bodzioch, B. Dejaegher, D. Mangelings, C. Rivière, V. Nguyen Thi Hong, M. Chau Van, J. Quetin-Leclerq, Y. Vander Heyden
    Talanta 83 (2011) 1188-1197

  • /10/ Identification by LC-ESI-MS of flavonoids responsible for the antioxidant properties of Mallotus species from Vietnam
    Van N.T. Hong, C. Rivière, Q.T. Hong, G. Chataigné, N.N. Hoai, B. Dejaegher, C. Tistaert, T.N.T. Kim, K.P. Van, Y. Vander Heyden, M.C. Van, J. Quetin-Leclercq
    Natural Product Communication 6 (2011) 813-818

  • /11/ Chemical constituents of Mallotus macrostachyus growing in Vietnam and cytotoxic activity of some cycloartane derivatives
    N.H. Nam, P.V. Kiem, C.V. Minh, N.K. Ban, N.P. Thao, N.X. Cuong, D.T. Thao, C. Tistaert, B. Dejaegher, A. Gordien, Y. Vander Heyden, J. Quetin-Leclercq
    Phytochemistry Letters 4 (2011) 348-352

  • /12/Near-infrared spectroscopy for the in-line and real-time monitoring of protein conformational stability during freeze-drying
    S. Pieters, T. De Beer, J.C. Kasper, W. Friess, D. Boulpaep, O. Waskiezwicz, C. Tistaert, Y. Vander Heyden
    Analytical Chemistry 84 (2012) 947-955

  • /13/ Multivariate data analysis to evaluate the fingerprint peaks responsible for the cytotoxic activity of Mallotus species
    C. Tistaert, B. Dejaegher, N. Nguyen Hoai, G. Chataigné, C. Rivière, V. Nguyen Thi Hong, M. Chau Van, J. Quetin-Leclerq, Y. Vander Heyden
    Submitted for publication

  • /14/ N-methyl-5-carboxamide-2-pyridone from Mallotus barbatus: a chemosystematic marker in the sub-tribe Rottlerinae of the Euphorbiaceae
    C. Rivière, V. Nguyen Thi Hong, N. Nguyen Hoai, B. Dejaegher, C. Tistaert, K.P. Van, Y. Vander Heyden, M. Chau Van, J. Quetin-Leclercq
    Submitted for publication

  • /15/ Development of HPLC fingerprints for a set of Mallotus and Phyllantus samples and their classification
    M. Goodarzi, B. Dejaegher, C. Tistaert, A. Huong Le Tuan, N. Nguyen Hoai, M. Chau Van, J. Quetin-Leclercq, Y. Vander Heyden
    Submitted for publication

  • /16/ Potential antioxidant compounds in Mallotus and Phyllantus species
    S. Thiangthum, B. Dejaegher, M. Goodarzi, C. Tistaert, A. Gordien,, N. Nguyen Hoai, M. Chau Van, J. Quetin-Leclercq, L. Suntornsuk, Y. Vander Heyden
    Submitted for publication

  • /17/ Multi-way alignment based on Multivariate Curve Resolution and Correlation Optimized Warping
    C. Tistaert, Y. Vander Heyden
    Draft completed

  • /18/ Chromatography or spectroscopy for the quality control of Citri reticulatae pericarpium: a trade-off between information and speed
    C. Tistaert, D. Verstraeten, Y. Vander Heyden
    In preparation

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Oral Presentations

  • /1/ Identification of peaks from HPLC fingerprints responsible for the antioxidant activity of Mallotus species
    B. Dejaegher, C. Tistaert, N. Nguyen Hoai, M. Chau Van, N. Nguyen Thi Hong, C. Rivière, J. Quetin-Lerclerq, J. Smeyers-Verbeke, Y. Vander Heyden
    11th Internation Conference on Chemometrics in Analytical Chemistry (CAC 2008) - June 30th-July 4th 2008 - Montpellier - France

  • /2/ Indication and identification of potential antioxidant compounds in Mallotus species fingerprints
    C. Tistaert, B. Dejaegher, N. Nguyen Hoai, M. Chau Van, V. Nguyen Thi Hong, G. Chataigné, C. Rivière, J. Quetin-Leclercq, Y. Vander Heyden
    14th Forum of Pharmaceutical Sciences - May 14th-15th 2009 - Blankenberge - Belgium

  • /3/ Pressurized capillary electrochromatography as an alternative technique to high-performance liquid chromatography for the indication of active compounds in Mallotus species
    S. Pieters, K. Bodzioch, C. Tistaert, G. Alaerts, B. Dejaegher, D. Mangelings, Y. Vander Heyden
    14th Forum of Pharmaceutical Sciences - May 14th-15th 2009 - Blankenberge - Belgium

  • /4/ Indication and identification of potential antioxidant compounds in Mallotus species fingerprints
    C. Tistaert, B. Dejaegher, N. Nguyen Hoai, M. Chau Van, V. Nguyen Thi Hong, G. Chataigné, C. Rivière, J. Quetin-Leclercq, J. Smeyers-Verbeke, Y. Vander Heyden
    Dag van het Farmaceutisch Onderzoek - June 2nd 2009 - Lamot Congres- en erfgoedcentrum - Mechelen - Belgium

  • /5/ Indication and identification of potential antioxidant compounds in Mallotus species fingerprints
    C. Tistaert, B. Dejaegher, N. Nguyen Hoai, M. Chau Van, V. Nguyen Thi Hong, G. Chataigné, C. Rivière, J. Quetin-Leclercq, Y. Vander Heyden
    11th Scandinavian Symposium on Chemometrics (SSC11) - June 8th-11th 2009 - Loen - Norway

  • /6/Identification of antioxidative compounds in Mallotus species combining chemometrical treated fingerprints with HPLC-MS
    C. Tistaert, B. Dejaegher, G. Chataigné, N. Nguyen Hoai, C. Rivière, M. Chau Van, J. Quetin-Leclercq, Y. Vander Heyden
    Belgian Society for Mass Spectrometrie 2010 - April 16th 2010 - Woluve - Belgium

  • /7/ Improving MS identification of Bacillus Subtilis delta-prpE and 168 proteins with the use of QSRR-based peptides retention times prediction in RP-HPLC
    K. Macur, T. Baczek, R. Kaliszan, C. Tistaert, B. Dejaegher, Y. Vander Heyden Drug analysis 2010 - September 21st-24th 2010 - University of Antwerp - Belgium

  • /8/ Data handling of chromatographic herbal fingerprints
    B. Dejaegher, C. Tistaert, M. Dumarey, G. Alaerts, Y. Vander Heyden
    12th International Conference on Chemometrics in Analytical Chemistry (CAC-2010) - October 18th-21th 2010 - Antwerp - Belgium

  • /9/ Chromatographic herbal fingerprints: Development, Validation, and Data Handling
    B. Dejaegher, C. Tistaert, M. Dumarey, G. Alaerts, Y. Vander Heyden
    Research on fingerprints of Chinese Materia Medica to develop standard and research protocols evaluating their identity, safety, and reproducibility - December 17th 2010 - Brussels - Belgium

  • /10/ Basic unsupervised and supervised multivariate data analysis
    B. Dejaegher, C. Tistaert, M. Goodarzi, M. Dumarey, G. Alaerts, Y. Vander Heyden
    Workshop Metabolomics: Basics and Applications to Plant Sciences - April 11th-15th 2011 - Leiden - The Netherlands

  • /11/ Resolution of spectrally rank deficient MCR-ALS components in 2D-LC-DAD analysis
    C. Tistaert, Y. Vander Heyden, S. C. Rutan
    Belgian Chemometric Society - workshop on multivariate curve resolution – May 6th 2011 – Brussels – Belgium

  • /12/ Resolution of spectrally rank deficient MCR-ALS components in 2D-LC-DAD analysis
    C. Tistaert, Y. Vander Heyden, S. C. Rutan
    15th Forum of Pharmaceutical Sciences - May 12th-13th 2011 - Spa – Belgium

  • /13/ Near-infrared spectroscopy as a process analyzer for the in-line and real-time monitoring of drying-induced protein denaturation during freeze drying
    S. Pieters, T. De Beer, J.C. Kasper, D. Boulpaep, O. Waszkiewicz, C. Tistaert, W. Friess, Y. Vander Heyden
    15th Forum of Pharmaceutical Sciences - May 12th-13th 2011 - Spa – Belgium

  • /14/ Data analysis of HPLC fingerprints from Mallotus and Phyllantus samples
    S. Thiangthum, B. Dejaegher, M. Goodarzi, C. Tistaert, Y. Vander Heyden
    15th Forum of Pharmaceutical Sciences - May 12th-13th 2011 - Spa – Belgium

  • /15/ Experimental designs for the optimization of separation techniques
    B. Dejaegher, C. Tistaert, M. Goodarzi, G. Alaerts, Y. Vander Heyden
    Master Class Separation Techniques in Life Sciences – May 18th 2011 – Breda – The Netherlands

  • /16/ Chromatographic herbal fingerprints: development, validation and data handling
    B. Dejaegher, C. Tistaert, M. Goodarzi, G. Alaerts, Y. Vander Heyden
    Kwaliteitsaspecten van Geneeskrachtige Planten, Nederlandse Vereniging voor GeneeskruidenOnderzoek (NVGO) - May 27th 2011 - Strombeek-Bever – Belgium

  • /17/ Resolution of spectrally rank deficient MCR-ALS components in 2D-LC-DAD analysis
    C. Tistaert, Y. Vander Heyden, S. C. Rutan
    12th Scandinavian Symposium on Chemometrics (SSC12) - June 7th-10th 2011 - Billund – Denmark

  • /18/ Herbal fingerprints: development and extraction of information
    Y. Vander Heyden, G. Alaerts, M. Dumarey, C. Tistaert, B. Dejaegher
    Fourteenth International Meeting on Recent Developments in Pharmaceutical Analysis - September 21st – 24th 2011 – Pavia – Italy

  • /19/ Classification of HPLC fingerprints for a set of Mallotus and Phyllantus samples
    M. Goodarzi, B. Dejaegher, A. Hoang Le Tuan, N. Nguyen Hoai, M. Chau Van, J. Quetin-Leclercq, Y. Vander Heyden
    Fifth International Chemometrics Research Meeting – September 25th – 29th 2011 – Berg en Dal – The Netherlands

  • /20/ Quality control of Citri reticulatae pericarpium: exploratory analysis and discrimination amongst other Citrus species
    C. Tistaert, Y. Vander Heyden
    2nd workshop on Food Chemistry and Biotechnology – October 18th -19th 2011 – Belgrade – Serbia

  • /21/ Resolution of spectrally rank deficient MCR-ALS components in LC×LC-DAD analysis
    C. Tistaert, Y. Vander Heyden, S. C. Rutan
    12th International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analyzers - February 1st – 3th 2012 - Bruges – Belgium

  • /22/ Herbal fingerprints: development and extraction of information
    Y. Vander Heyden, G. Alaerts, M. Dumarey, C. Tistaert, B. Dejaegher
    12th International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analyzers - February 1st – 3th 2012 - Bruges – Belgium

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Poster Presentations

  • /1/ Determination of antioxidative compounds in Mallotus species fingerprints using linear multivariate calibration techniques
    C. Tistaert, B. Dejaegher, N. Nguyen Hoai, C. Rivière, V. Nguyen Thi Hong, M. Chau Van, J. Quetin-Leclerq, Y. Vander Heyden
    9th Chemometrics Symposium (Belgian Chemometrics Society) - April 11th 2008 - Gembloux - Belgium

  • /2/ Determination of antioxidative compounds in Mallotus species fingerprints using linear multivariate calibration techniques
    C. Tistaert, B. Dejaegher, N. Nguyen Hoai, C. Rivière, V. Nguyen Thi Hong, M. Chau Van, J. Quetin-Leclerq, Y. Vander Heyden
    19th International Symposium on Pharmaceutical and Biomedical Analysis (PBA 2008) - June 8th-12th 2008 - Gdansk - Poland

  • /3/ Indication and identification of potential antioxidant compounds in Mallotus species fingerprints
    C. Tistaert, B. Dejaegher, N. Nguyen Hoai, M. Chau Van, V. Nguyen Thi Hong, G. Chataigné, C. Rivière, J. Quetin-Leclercq, Y. Vander Heyden
    25th Annual Symposium on Chemometrics: Dynamic chemometrics - May 28th 2009 - Delft - The Netherlands

  • /4/ Screening for antioxidant compounds in pressurized capillary electrochromatography fingerprints from Mallotus species using partial least squares algorithms
    S. Pieters, K. Bodzioch, C. Tistaert, G. Alaerts, B. Dejaegher, D. Mangelings, Y. Vander Heyden
    25th Annual Symposium on Chemometrics: Dynamic chemometrics - May 28th 2009 - Delft - The Netherlands

  • /5/ Dissimilar chromatographic systems to identify peaks responsible for the antioxidant activity of Mallotus species
    C. Tistaert, B. Dejaegher, P. Doan Lan, C. Rivière, M. Chau Van, J. Quetin-Leclercq, Y. Vander Heyden
    11th Scandinavian Symposium on Chemometrics (SSC11) - June 8th-11th 2009 - Loen - Norway

  • /6/ Signal increase using experimental design for a capillary electrophoresis separation of poliovirus particles
    I. Oita, H. Halewyck, C. Tistaert , B. Dejaegher, B. Thys, B. Rombaut, Y. Vander Heyden
    11th Scandinavian Symposium on Chemometrics (SSC11) - June 8th-11th 2009 - Loen - Norway

  • /7/ Screening for antioxidant compounds in Mallotus species using partial least squares regression models built on pressurized capillary electrochromatography fingerprints
    S. Pieters, K. Bodzioch, C. Tistaert, G. Alaerts, B. Dejaegher, D. Mangelings, Y. Vander Heyden
    PhD course on Process Analytical Technology, Technical University of Denmark (DTU) - June 21-26th 2009 - Lyngby - Denmark

  • /8/ Pressurized capillary electrochromatography, a useful technique to screen for antioxidant compounds in Mallotus fingerprints?
    S. Pieters, K. Bodzioch, C. Tistaert, G. Alaerts, B. Dejaegher, D. Mangelings, Y. Vander Heyden
    Recent Developments in Pharmaceutical Analysis (RDPA) 2009, 13th international meeting - September 9-12th 2009 - Milan - Italy

  • /9/ Dissimilar chromatographic fingerprints to indicate compounds with antioxidant activity
    C. Tistaert, B. Dejaegher, G. Chataigné, P. Doan Lan, C. Rivière, M. Chau Van, J. Quetin-Leclercq, Y. Vander Heyden
    Chimiométrie 2009 - November 30th - December 1st 2009 - Paris - France

  • /10/Identification of antioxidative compounds in Mallotus species combining chemometrical treated fingerprints with HPLC-MS
    C. Tistaert, B. Dejaegher, G. Chataigné, N. Nguyen Hoai, C. Rivière, V. Nguyen Thi Hong, M. Chau Van, J. Quetin-Leclercq, Y. Vander Heyden
    26th Annual Symposium on Chemometrics: Knowledge integration & visualization - May 20th 2010 - Utrecht - The Netherlands

  • /11/Identification of antioxidative compounds in Mallotus species combining chemometrical treated fingerprints with HPLC-MS
    C. Tistaert, B. Dejaegher, G. Chataigné, N. Nguyen Hoai, C. Rivière, V. Nguyen Thi Hong, M. Chau Van, J. Quetin-Leclercq, Y. Vander Heyden
    PhD Research Day 2010 ("Dag van de Doctorandi 2010") - May 28th 2010 - VUB - Brussels - Belgium

  • /12/ Quality control of Citri reticulatae pericarpium based on chemometrically treated HPLC fingerprints
    C. Tistaert, A. Szandrach, L. Thierry, B. Dejaegher, Y. Vander Heyden
    12th International Conference on Chemometrics in Analytical Chemistry (CAC-2010) - October 18th-21th 2010 - Antwerp - Belgium

  • /13/ Quality control of Citri reticulatae: exploratory analysis and discrimination
    C. Tistaert, A. Szandrach, L. Thierry, B. Dejaegher, Y. Vander Heyden
    Research unlimited - April 5th 2011 - Brussels – Belgium

  • /14/ Quality control of Citri reticulatae: exploratory analysis and discrimination
    C. Tistaert, A. Szandrach, L. Thierry, B. Dejaegher, Y. Vander Heyden
    12th Scandinavian Symposium on Chemometrics (SSC11) - June 7th-10th 2011 - Billund - Denmark

  • /15/ Data handling of chromatographic herbal fingerprints
    B. Dejaegher, C. Tistaert, M. Dumarey, G. Alaerts, Y. Vander Heyden
    12th Scandinavian Symposium on Chemometrics (SSC11) - June 7th - 10th 2011 - Billund – Denmark

  • /16/ Classification of HPLC fingerprints for a set of Mallotus and Phyllantus samples
    M. Goodarzi, B. Dejaegher, A. Hoang Le Tuan, N. Nguyen Hoai, M. Chau Van, J. Quetin-Leclercq, Y. Vander Heyden
    Fifth International Chemometrics Research Meeting – September 25th – 29th 2011 – Berg en Dal – The Netherlands

  • /17/ Quality control of Citri reticulatae pericarpium: exploratory analysis and discrimination
    C. Tistaert, A. Szandrach, L. Thierry, B. Dejaegher, Y. Vander Heyden
    34th symposium on chromatographic methods of investigating the organic compounds – June 8th – 10th 2011 – Szczyrk - Poland

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Awards

    Dissimilar chromatographic systems to identify peaks responsible for the antioxidant activity of Mallotus species
    C. Tistaert , B. Dejaegher, P. Doan Lan, C. Rivière, M. Chau Van, J. Quetin-Leclercq, Y. Vander Heyden

    Awarded as runner-up for the Wiley Award for the best poster at the 11th Scandinavian Symposium on Chemometrics (SSC11) - June 8th-11th 2009 - Loen - Norway

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Memberships

  • Belgisch Genootschap voor Farmaceutische Wetenschappen (BGFW) (Belgian Society of Pharmaceutical Sciences)

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Coordinates

Christophe Tistaert
Vrije Universiteit Brussel
Faculteit Geneeskunde en Farmacie
Farmaceutisch Instituut
Vakgroep Analytische Scheikunde en Farmaceutische Technologie
Laarbeeklaan 103
B-1090 Brussels Belgium
Tel: (+32) 2 477 47 26
Fax: (+32) 2 477 47 35
Email:


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